{"_buckets": {"deposit": "ca64baa0-cbcc-49d5-b89f-f08fc92a5c00"}, "_deposit": {"created_by": 4, "id": "1221", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "1221"}, "status": "published"}, "_oai": {"id": "oai:hirokoku-u.repo.nii.ac.jp:00001221", "sets": ["124"]}, "author_link": [], "control_number": "1221", "item_10002_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2023-03-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "30", "bibliographicPageStart": "21", "bibliographic_titles": [{"bibliographic_title": "HIU健康科学ジャーナル"}]}]}, "item_10002_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10002_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "近年、口腔内細菌と様々な全身疾患との閧連が注目されてぃる。これまでの研究において、cnm およびpa遺伝子を持つミュータンス菌(cnm/pa+ミュータンス菌)が非アルコール性脂肪肝炎(NASH)の発症に影響を及ぼすことが示唆されており、早期発見が課題となっている。 本研究では遺伝子増幅法の 1つである LOOP-mediated isthermal amplification(LAMP)法を用いて、 cnm+/pa+ミュータ ンス菌を短時間かつ特異的に増幅するプライマーの作製および条件を検討した。LAMP用プライマーをcnmは4種類(cnm1, 2、 3、 4)、paは3種(pa1 、2、3)設計し、LAMPによる増幅をした結果、短時聞に増幅したプライマーは cnm2 およびPa1であった。 また、ソブリヌス菌、ジンジバリス菌、カンジダ菌を用いて特異性を見た結果、これらのプライマーはミ ュータンス菌以外の口腔内細菌を増幅しなかった。さらに、健常者の唾液を用いた 検討を行った結果、約4人に 1人が NASH増悪因子としてcnm+pa+ミュータンス菌を保菌している事が明らかとなった。", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}]}, "item_10002_full_name_3": {"attribute_name": "著者(英)", "attribute_value_mlt": [{"names": [{"name": "Tomita, Syota", "nameLang": "en"}]}, {"names": [{"name": "Takahara, Yuka", "nameLang": "en"}]}, {"names": [{"name": "Suzuki, Tsukika", "nameLang": "en"}]}, {"names": [{"name": "Nakagaki, Konoka", "nameLang": "en"}]}, {"names": [{"name": "Kimura, Rumi", "nameLang": "en"}]}, {"names": [{"name": "Nagamine, Kentaro", "nameLang": "en"}]}]}, 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"creatorNameLang": "ja-Kana"}]}, {"creatorNames": [{"creatorName": "鈴木, 月花", "creatorNameLang": "ja"}, {"creatorName": "スズキ, ツキカ", "creatorNameLang": "ja-Kana"}]}, {"creatorNames": [{"creatorName": "中垣, 好花", "creatorNameLang": "ja"}, {"creatorName": "ナカガキ, コノカ", "creatorNameLang": "ja-Kana"}]}, {"creatorNames": [{"creatorName": "木村, 留美", "creatorNameLang": "ja"}, {"creatorName": "キムラ, ルミ", "creatorNameLang": "ja-Kana"}]}, {"creatorNames": [{"creatorName": "長嶺, 憲太郎", "creatorNameLang": "ja"}, {"creatorName": "ナガミネ, ケンタロウ", "creatorNameLang": "ja-Kana"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2023-06-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "jhs02_021.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", 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"subitem_title_language": "ja"}, {"subitem_title": "Detection of oral mutans associated with systemic disease", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "4", "path": ["124"], "permalink_uri": "https://doi.org/10.60172/0000001221", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-06-19"}, "publish_date": "2023-06-19", "publish_status": "0", "recid": "1221", "relation": {}, "relation_version_is_last": true, "title": ["全身疾患に関わる口腔内ミュータンス菌の検出"], "weko_shared_id": -1}
https://doi.org/10.60172/0000001221
https://doi.org/10.60172/0000001221